With the progress of science and the discovery of various drawbacks of antibiotics, people have disputed the scientific and reliability of antibiotic use, and began to look for green feed additives that effectively replace antibiotics.

Boluohui is the fruit of poppy Coboluohui genus. It has the effect of clearing heat and detoxifying, killing insects and relieving itching. It can be used in clinical treatment of vaginitis, pneumonia, skin diseases, hepatitis and has anti-tumor effect. Because the active active ingredient is a natural substance, it is easy to degrade without residue after use, so the research and application of it as a feed additive has received more and more attention.

1 Main Components

Studies at home and abroad show that borohuiline contains chelidorubin, sanguinarine, sanguinarine oxide, dehydrocorydaline, borohuiline, berberine, coptin, xamine, A, B, c and other alkaloids. These alkaloids are isoquinoline derivatives and have many pharmacological effects and uses. Sanguinarine, berberine and borlogonine have broad-spectrum bacteriostatic effects.

2 Pharmacological effects of boluigi

It is distributed in some parts of south China, and is often used as soil pesticide, which is a traditional folk pesticide. Bo fall back hard, cold, return to the liver, large intestine meridian, have big poison, can not be taken orally, clearing heat and detoxification, Huoxue powder, qufeng deswelling, insecticide, for injury, rheumatism, rheumatism, swollen sore, lower limb ulcer, eczema, burns, vaginal trichomoniasis, nematode disease, external use appropriate amount, decocting water or ground powder and dressing, or take fresh products to crush the affected area.

2.1 Anti-inflammatory and antibacterial effects

Berberine, sanguinarine, and berberine, which are widely found in Boilohume, can inhibit and kill some bacteria, fungi and viruses, such as Staphylococcus aureus, Candida alba, Hypomyces lanoides and influenza virus A to varying degrees. Studies have shown that sanguinarine and borocladine have strong anti-inflammatory and inhibitory effects on oral bacteria, so they are used in the treatment of oral inflammation, and the mixture of 5% concentration of the two is an effective agent for the treatment of periodontitis.

The alkaloids of Borohuhuei are the effective components of antibacterial action, and its decoction has strong inhibitory effect on many gram-positive and Gram-negative bacteria and leptospira. Chelidorine, sanguinarine and boroheline also have different degrees of inhibition on Staphylococcus aureus, Bacillus subtilis, Bacillus sarcina, Escherichia coli, Proteus, Pseudomonas aeruginosa and some fungi. Ethoxyssanguinarine also has a strong killing effect on leptospira in vitro.

2.2 Insecticidal effect

Yuan Daozhong et al. observed the killing effect of total alkali of bolui on the third stage larvae of maggot flies, and found that the concentration of total alkali of Bolui corresponding to 0.16mmoL/100mL equivalent H₂SO and total alkali of Bolui can kill all larvae 100% within 24 hours, and its insecticidal efficacy is equivalent to 0.025mmol/L deltamethrin. Experiments have shown that the isoquinoline alkaloids contained in Boroguei show strong killing activity against strongyloides, which has been proved to be an effective treatment or precursor drug with research potential for strongyloides. Boluigi not only has killing or inhibiting effect on nematodes, trypanosoma and Plasmodium parasites in animals or humans, but also has good killing activity on arthropods and lepidoptera environmental pests in vitro. It is a kind of natural source insecticide with broad spectrum.

2.3 Improve liver function and enhance immunity

Boluohui significantly improved liver function in acute liver injury models induced by carbon tetrachloride and galactosamine. In the rat model of chronic liver injury caused by carbon tetrachloride, Boluohui can significantly reduce serum LDH level, reduce animal mortality, increase serum A/C ratio, effectively protect liver cell membrane and inhibit liver fibrosis. The function of T and B lymphocytes can also be significantly enhanced.

2.4 Anti-tumor effect

Borohuilei alkaloids had inhibitory effect on KB, P388, W256 tumor cells. Sanguinarine has a weak antitumor effect on ascites. Other experiments have shown that the total alkaloids of boluogi have obvious inhibitory effect on tumor bearing animals (solid tumors).

2.5 Other Effects

The chelidonine contained in Borohuizi has the effects of relieving cough, relieving asthma and relieving pain. The blood root can inhibit cholinesterase activity, strengthen cardiac activity, stimulate salivary secretion, and have diuretic and peripheral anti-adrenergic sympathetic effects. Protoopioid and allocryptopine showed inhibitory effects on isolated guinea pig hearts.

3 Bo fall back application

1 Application in veterinary medicine

Application in the prevention and treatment of animal bacterial diseases

Boluohui sulfate injection has the functions of clearing heat and detoxification, antibacterial and anti-inflammatory, and has specific effects on many diseases such as swine yellow dysentery, white dysentery, edema disease, paratyhoid fever and transmissible gastroenteritis of pigs, without resistance, residue and side effects. It is safe and reliable to use, and has been included in the 96th edition of Veterinary Drug Quality Standard of the Ministry of Agriculture. In vitro and veterinary clinical tests showed that the minimum inhibitory concentration (MIC) of Boluohuei injection against Escherichia coli was 7.8lug/mL, and the total effective rate of treating yellow and white dysentery of piglets was 80%. And has the advantages of small consumption and low cost. Boluohui injection was prepared by using the active ingredients extracted from Boluohui. Clinical tests showed that it had good therapeutic effect on swine erysipelas, piglet dysentery, enteritis, avian cholera and avian dysentery.

Application in the prevention and treatment of parasitic diseases

It has killing effect on maggots, and its action substance is alkaloid. Gong Zhongfu et al. observed the killing activity of 19 crude methanol extracts from plants such as Boluohui against Prurophora rabbit through in vitro insecticidal tests. The results showed that the aqueous suspension containing 50% of the crude methanol extracts of the original plant, such as Boluohuei, Baibu, Tangerine peel, dichotoma bark, nimbus bark, matrine bark and Baibu, could kill the adult pruritus rabbit within 4h, and Boluohuei and Baibu could kill the adult pruritus rabbit within 2h. The activity of the aqueous solution was no less than 2mg/L of avermectin.

2 Application in feed

Sanguinarine was approved by the Ministry of Agriculture in 1999 as a seasoning agent and spice added to animal feed. In addition, boilback is also added to feed, For example, Beijing Xingrenhe Feed Group Bao Sheng Huang Pharmaceutical Co., LTD., the use of Seneciang, boluhui, double Hualien, spectacle of mycin, Linkeramycin, amoxicillin and other treatment of chicken and duck various viral intestinal diseases, E. coli, diarrhea, yellow and white dysentery typhoid, paratyphus, viral hepatitis, ulcerative, hemorrhagic, red blood dysentery, green stool, watery stool, appetite, spirit

Intestinal disease syndrome such as deficiency and coccidia. Pavel Kosina et al reported that the daily intake of borlogol alkaloids in pigs did not exceed 5mg/kg.BW

It's safe. In foreign countries, sanguinarine and chelidonine are used in feed to stimulate animal appetite to increase feed intake, protect intestinal amino acids must be degraded by microorganisms, thus promoting animal growth.

4 Prospects and prospects

It has good efficacy and is widely used in clinical practice, and also has great advantages in the treatment and prevention of some animal diseases, especially in animal production, in some cases where antibiotics cannot be used in large quantities due to drug residues, replacing some antibiotics with it plays an important role in ensuring the health and sustainable development of livestock production. However, due to the complex composition and certain toxicity, its application is limited.

With the application of new high-tech methods in the separation, extraction and purification of plant extracts, it provides a strong technical guarantee for the research and application of bodilopolis alkaloids. In addition, Bodilopolis is widely distributed in China and easy to cultivate and manage. Therefore, Bodilopolis has broad market prospects and huge economic value.